WebFeb 22, 2024 · Chimerism determination. Screening of recipient and donor samples showed informative markers for all the 28 allo-SCT patients . In order to test our initial hypothesis, all the peripheral blood samples corresponding to the 28 leukaemia patients were simultaneously analysed by qPCR and dPCR methods, using the same … WebSep 2, 2024 · Chimerism monitoring No patient had an IMC without previous or concomitant MRD detection. After isolated MRD detection, IMC was subsequently detected in 6/22 (27%) of cases (median recipient...
Chimerism Monitoring after Allogeneic Hematopoietic Stem …
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WebDec 9, 2024 · Chimerism analysis is a surrogate indicator of graft rejection or relapse after allogeneic hematopoietic stem cell transplantation (HSCT). Although short tandem … WebNov 26, 2024 · It is well known that chimerism monitoring is an important diagnostic tool for assessing the risk of relapse after allo-HSCT in patients with malignant diseases, especially in those, who lack specific markers for tracking residual disease [4]. WebJan 1, 2024 · The chimerism level was quantified using the Devyser Chimerism kKt following the manufacturer's instructions. This kit is based on multiplex PCR using a range of 24 highly informative markers distributed over 17 chromosomes suitable for the screening of a recipient-donor pair and monitoring of chimerism status followed by specific Illumina … greens house of care san augustine