Cisplatin efficacy

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August undefined, 2024

WebJul 8, 2024 · Multicenter, randomized, open-label, parallel group phase 2 study to assess the efficacy and tolerance of four combinations of CBP501, cisplatin, and nivolumab administered once every 21 days to patients with stage IV exocrine pancreatic cancer and WBC < 10,000/mm3 at screening. WebMar 15, 2024 · The incidence of ototoxicity induced by cisplatin has been estimated to be 36% of adult patients with cancer and 40%-60% of pediatric patients.2 …

Frontiers Cisplatin Promotes the Efficacy of Immune Checkpoint ...

WebSep 27, 2016 · PURPOSE Paclitaxel, ifosfamide, and cisplatin (TIP) achieved complete responses (CRs) in two thirds of patients with advanced germ cell tumors (GCTs) who relapsed after first-line chemotherapy with cisplatin and etoposide with or without bleomycin. We tested the efficacy of first-line TIP in patients with intermediate- or poor … WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … northeastern health system human resources

Chemoradiotherapy with paclitaxel liposome plus …

WebJun 1, 2024 · A phase 2 trial of durvalumab in combination with gemcitabine and cisplatin demonstrated promising efficacy, with an objective response rate of 72% and a median overall survival of 20.2 months and without dose-limiting toxicity, in a nonrandomized, single-center study, establishing proof of concept for this approach in advanced biliary tract ... WebCisplatin : an old drug with a newfound efficacy -- from mechanisms of action to cytotoxicity Although cisplatin has been used for a long time, only recently its exact mechanism of action has been better defined. WebJul 30, 2024 · In this study, we proposed a comprehensive TME modulation strategy that modifies multiple elements of the TME in order to enhance cisplatin anticancer efficacy. To do so, we prepared biocompatible lipid-coated CaO 2 /cisplatin nanoparticles (LipoCaO 2 /DDP) by the reverse microemulsion method. northeastern health system in tahlequah ok

Efficacy and safety of weekly versus triweekly cisplatin... : Medicine

Weekly versus 3‐weekly cisplatin along with radiotherapy for ...

WebApr 11, 2024 · To evaluate if STAT3 KD can enhance the efficacy of cisplatin therapy for MB, we treated HD-shSTAT3 and ONS-shSTAT3 cells with an increasing concentration … WebSep 15, 2024 · Cisplatin has activity against multiple tumor types and was approved for use by the United States in 1978. Current indications include testicular, ovarian and bladder cancer. It is also used in combination with other agents in … northeastern health systemWebMay 26, 2024 · Efficacy The full analysis set included 26 (83.9%) patients who received at least one dose of study drug, had a baseline scan, and had at least one post-baseline disease assessment. Four (15.4%)... northeastern health system physical therapy

"WebJan 13, 2024 · Indeed, after decades of research on antioxidants optimized for scheduling, dose, potency, and method of administration, no antioxidant therapy has demonstrated enough efficacy to be widely accepted as a therapy for cisplatin ototoxicity. Despite some limitations of antioxidants, several have moved toward a clinical trial. " - Cisplatin efficacy

Cisplatin efficacy

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable... WebDec 30, 2024 · Another large cohort study by Zhu et al [ 21] reported that weekly cisplatin was associated with ...

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WebCisplatin and nimotuzumab combined with concurrent chemoradiotherapy is safe and effective in the treatment of locally advanced cervical cancer, both local tumor control and PFS rate are excellent, and the patient's tolerance is good, so it … WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II …

WebFeb 16, 2024 · Warnings. Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys.. Call your doctor if you have a fever, mouth … WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have …

WebOct 5, 2014 · Cisplatin is cleared by the kidney by both glomerular filtration and tubular secretion (Yao, Panichpisal et al., 2007; Ishida, Lee et al., 2002) Cisplatin … WebJul 3, 2024 · These include blockade of cisplatin entry into the cochlear fluid or hair cells. Further, antioxidants are among the most extensively studied agents due to the importance of ROS in ototoxicity. However, a concern exists that the chemotherapeutic efficacy of cisplatin may be reduced (Block et al., 2009). Reductions in inflammatory cytokine ...

WebAn "accidental" discovery leads to cisplatin.Because platinum was thought to have no biological activity, Dr. Rosenberg and his colleagues put platinum electrodes into a solution containing the common laboratory bacteria E. …

WebNov 17, 2024 · Cisplatin has been widely used for a variety of cancer chemotherapies. In the guidelines for CINV, cisplatin is classified as a high-emetic-risk antineoplastic agent, and several agents – i.e. NK1 receptor antagonist (NK1RA), dexamethasone and 5-hydroxytryptamine-3 receptor antagonist (5-HT3RA) – are recommended for use with … northeastern health insurance+plansWebOct 1, 2024 · Enhancement of cisplatin efficacy by lipid-CaO 2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment. Hypoxia, acidosis and high … how to restore remindersWebAug 8, 2024 · Background: Cisplatin is one of the frontline anticancer agents. However, development of cisplatin-resistance limits the therapeutic efficacy of cisplatin-based … how to restore recycle bin deleted filesWebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive bladder urothelial carcinoma. Additionally, he also developed severe dizziness, nausea and vomiting during treatment with gemcitabine and cisplatin for metastatic high-grade non … northeastern health system miami okWebThe efficacy of cisplatin must be improved for the treatment of UTUC because most patients with UTUC are older and may have renal insufficiency. The inadequate dose of cisplatin consequently leading to a poor outcome is a clinical challenge. northeastern health system sallisawWebChemotherapeutics that damage DNA, such as cisplatin, have been the mainstay of cancer treatment for decades . However, all too often the efficacy of such DNA-damaging chemotherapy is severely limited by intrinsic and acquired drug resistance, as well as by the induction of secondary malignancies. northeastern health system okWebJun 11, 2024 · PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD. PFS as assessed by blinded independent central review (BICR) will be presented. northeastern health system patient portal