Cisplatin with rt
WebFeb 2, 2024 · The benefit of adding concomitant high-dose cisplatin to adjuvant radiotherapy (RT) for resected head and neck squamous cell carcinoma (HNSCC) was … WebJun 29, 2011 · Cisplatin is the most common agent used in combination with RT, and is one of the best studied. The standard regimen is three-weekly high-dose (100 mg/m 2) cisplatin (three cycles) concurrent with RT ( 2, 3 ). However, cisplatin at a dose of 100 mg/m 2 with concomitant RT is associated with significant acute and late toxicities ( 2, 4, …
Cisplatin with rt
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WebMay 27, 2024 · However, when cetuximab-based chemoradiotherapy was compared with the combination of RT and cisplatin (a crosslinking cytotoxic chemotherapy), OS, PFS, and LRC were significantly worse in unselected patients with HPV-positive oropharyngeal cancer who received cetuximab rather than cisplatin ( 4, 5 ). WebBackground and purpose: In patients with head-and-neck cancer treated with chemoradiotherapy (CRT), a cisplatin-based regimen is often used. Several treatment schedules are accepted with a cumulative cisplatin dose of 200 mg/m (2) (CisCD200) given during radiotherapy.
WebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of …
WebIntroduction. Radiotherapy (RT) is the most common type of curative and palliative treatment for all cancer patients, including breast cancer patients. 1,2 Worldwide, breast cancers had totaled up to 2 million new cancer cases in the year 2024, which was approximately closed to the number of lung cancers and followed by colorectal, prostate and stomach cancers. … WebIn addition, no significant difference in overall survival was seen in the matched cohorts. ChemoRT with either cisplatin or carboplatin was superior to RT alone and RT with concurrent cetuximab. In the multivariable model, the adjusted hazard ratio of CSM for carboplatin relative to cisplatin was 1.01 (95% CI, 0.79–1.28; P=.94).
WebApr 12, 2024 · The patient was started on gemcitabine, cisplatin, and nanoparticle albumin-bound paclitaxel (nab-paclitaxel). After 3 months of chemotherapy, the patient's AFP increased to 43.8 ng/ml and her CA 19-9 increased to 21.4 U/ml. On repeat CT scan, the size of the tumor was stable, but there was suspected intraductal extension toward the …
WebApr 13, 2024 · Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic enhancement of cisplatin and radiation in both hpv-negative and -positive hnscc cell lines. ... For the combination of BKM120 and RT a clinical study with HNSCC was just completed and the respective results will be expected in the near future (NCT02113878). detailed lesson plan in making icingWebMar 23, 2012 · The study showed that tri-weekly cisplatin 75 mg/m2 concurrent to RT is feasible and increase 5-year survival rate significantly compared to weekly cisplatin 40 mg/m2 in patients with locally advanced cervical cancer (66.5% in the weekly arm, 88.7% in the tri-weekly arm; HR=0.375, 95% CI: 0.154-0.914, p= .03). detailed lesson plan in mapeh 6WebJan 25, 2016 · Arm A represents concurrent pemetrexed-cisplatin (Pem-Cis) and thoracic radiation therapy (TRT) followed by consolidation pemetrexed. Arm B represents concurrent etoposide-cisplatin (Eto-Cis) and TRT followed by one of three consolidation chemotherapy regimens of choice: Eto-Cis, vinorelbine-cisplatin (Vin-Cis), or paclitaxel-carboplatin … detailed lesson plan in mapeh 4WebMar 26, 2024 · The use of two doses of high-dose cisplatin concurrently with accelerated RT has been shown to be as effective as three doses with standard-fractionation RT and is an acceptable treatment alternative for patients with HPV-OPC, resulting in a 33% decrease in cumulative cisplatin dose. 57, 59 Decreasing the dose of cisplatin as part of … detailed lesson plan in mapeh 10WebAug 28, 2024 · The investigators primary hypothesis is that LD weekly cisplatin 40 mg/m² is associated with reduced frequency of severe hearing loss and improved hearing-related QOL when compared to conventional HD cisplatin 100 mg/m² days 1, 22 & 43 (control arm) in LASCCHN patients treated with CRT. detailed lesson plan in mapeh pdfWebCISplatin L01XA01 REFERENCES: 1. Rose P, Bundy BN, Watkins EB, et al. Concurrent CISplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 1999;340(15):1144-1153. 2. Cisplatin, Radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage 1B cervical carcinoma. chums pegasus shoesWebThe beneficial effects of cisplatin, which is the most widely used agent for CCRT in CC patients, whether alone or in combination with other drugs, were not independently … chums pencil pleat curtains