Web5 de dez. de 2008 · Author Summary As women age, the quality of their oocytes declines, causing the eggs they make to have a higher chance of producing a miscarriage or a child with birth defects. We used the roundworm C. elegans to study this problem. We show that oocyte quality declines in these small animals during aging, much as in mammals. … Web19 de fev. de 2024 · Therefore, apoptosis is involved in massive oocyte death after LSD1 inhibition but may not be the major cause. Inhibition of LSD1 results in extensive autophagy in oocytes and is related to oocytes death. To further ascertain whether autophagy was involved in oocytes death, we observed changes in LC3B in response to LSD1 levels.
Oocyte Development - Embryology - UNSW Sites
Web30 de dez. de 2024 · In addition, LONP1 ablation in mouse oocytes caused prolonged activation of the mtUPR, defective mitochondrial biosynthesis and function, and oocyte death. Mechanistically, LONP1 directly interacts with AIFM1, and LONP1 ablation led to the translocation of AIFM1 from the cytoplasm to the nucleus, causing apoptosis in mouse … Web31 de jan. de 2024 · Inhibition of mitochondrial ATP production ultimately leads to oocyte death [6, 60], an event foreshadowed by the collapse of ATP dependent functions … ctc cleveland ohio
Regulation of [Ca2+]i oscillations and mitochondrial activity by ...
Web11 de abr. de 2024 · Prednisone is one of the most used synthetic glucocorticoids during pregnancy. Epidemiological investigations suggested that prenatal prednisone therapy could affect fetal development, but systematic studies on its effects on ovarian development and the “toxic effect window” remained scarce. In this study, by simulating clinical application … Web5 de out. de 2013 · In addition, aberrant regulation of oocyte death as primordial follicles form may be the underlying cause of ovarian dysgerminoma, or germ cell tumors [7]. … Web19 de fev. de 2024 · Generally, if oogonia mitosis or oocyte meiosis progression is affected, oocytes will be abnormal or even dead. Some oocytes in fetal mouse ovaries initiate meiosis as early as 13.5 dpc. ctc coatings